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Issue 32, 2008
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Conformation change of collagen during the initial stage of biomineralization of calcium phosphate

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Abstract

The present work was designed to examine the interaction of collagen/calcium phosphate during the initial mineralization process. Circular dichroism analysis was performed to investigate the conformation change of collagen during the initial process. An ultraviolet photometer was used for turbidity measurements in situ to study the kinetic process of mineralization. It was revealed for the first time that during the initial mineralization process the collagen conformation changed markedly while amorphous/crystalline conversion and crystal ripening occurred. The mechanism for the conformation change was discussed based on the experimental results. The conformation change of the organic matrix may be a widespread phenomenon in biomineralization systems in the living body.

Graphical abstract: Conformation change of collagen during the initial stage of biomineralization of calcium phosphate

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Publication details

The article was received on 02 Apr 2008, accepted on 20 Jun 2008 and first published on 30 Jun 2008


Article type: Paper
DOI: 10.1039/B805467C
Citation: J. Mater. Chem., 2008,18, 3835-3840
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    Conformation change of collagen during the initial stage of biomineralization of calcium phosphate

    F. Z. Cui, Y. Wang, Q. Cai and W. Zhang, J. Mater. Chem., 2008, 18, 3835
    DOI: 10.1039/B805467C

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