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Issue 27-28, 2005
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Heavy metal analysis using a Heck-catalyzed cyclization to create coumarin

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Abstract

This paper describes a new method for heavy metal analysis via catalytic signal amplification. This signal amplification protocol relies upon an exogenous inhibitor for deliberate deactivation of an organometallic reaction that catalytically creates a fluorophore. When the deactivation process is performed in the presence of the analyte, competitive binding of the inhibitor with the analyte and the catalyst occurs. A Heck reaction creating a coumarin fluorophore with a high quantum yield was studied. 1,4,7,10,13-Pentaaza-cyclopentadecane was chosen as the inhibiting ligand to selectively coordinate pre-catalyst Pd(II) and analytes Cd(II), Ni(II), Co(II). Monitoring product fluorescent intensity in real time revealed the concentration of analyte.

Graphical abstract: Heavy metal analysis using a Heck-catalyzed cyclization to create coumarin

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Publication details

The article was received on 11 Feb 2005, accepted on 13 Apr 2005 and first published on 05 May 2005


Article type: Paper
DOI: 10.1039/B502199P
Citation: J. Mater. Chem., 2005,15, 2815-2819
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    Heavy metal analysis using a Heck-catalyzed cyclization to create coumarin

    Q. Wu and E. V. Anslyn, J. Mater. Chem., 2005, 15, 2815
    DOI: 10.1039/B502199P

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