Inductively coupled plasma mass spectrometry for the determination of platinum in animal tissues and a comparison with atomic absorption spectrometry

Abstract

Inductively coupled plasma mass spectrometry (ICP-MS) has been applied to the determination of platinum in blood, urine and tissue specimens taken from patients and experimental animals up to three months after the administration of cisplatin. Comparisons were made with graphite furnace atomic absorption spectrometry (GFAAS). Tissue specimens of from 0.1 to 300 g were prepared by nitric acid digestion and solution in dilute hydrochloric acid. As ICP-MS is highly specific and sensitive, giving detection limits below 0.1 µg l^–1, matrix effects were small and compensated for by an indium internal standard. A detection limit of ca. 10 µg l^–1 was obtained by GFAAS and matrix effects, particularly that of residual nitric acid, were much greater.