The conformational analysis of saturated heterocycles. Part XXVIII. 5-Alkoxy-1,3-dioxans

Abstract

cis–trans-Equilibrium constants have been determined for a series of 5-alkoxy-2-aryl-1,3-dioxans. The rotamer populations of the cis-derivatives have been investigated by dipole moments. The relative stabilities of the individual rotamers of the various conformers are discussed in terms of specific intramolecular interactions. The range of applicability of the semiquantitative method of conformational analysis by assignment of constant energies to specific intramolecular interactions is surveyed by reference to literature data.