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Issue 13, 2017
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An environmentally friendly protocol for oxidative halocyclization of tryptamine and tryptophol derivatives

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Abstract

An environmentally friendly and efficient protocol (KX/oxone) for oxidative halocyclization of tryptamine/tryptophol derivatives was developed and demonstrated with 28 examples and concise total synthesis of cyclotryptamine alkaloid protubonines A and B. The distinct advantage of this protocol over all previous methods is that no organic byproduct is generated from a halogenating agent or oxidant, thus greatly reducing the environmental impact of halocyclization and facilitating the post-reaction purification.

Graphical abstract: An environmentally friendly protocol for oxidative halocyclization of tryptamine and tryptophol derivatives

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Publication details

The article was received on 05 May 2017, accepted on 18 May 2017 and first published on 18 May 2017


Article type: Communication
DOI: 10.1039/C7GC01341H
Citation: Green Chem., 2017,19, 2952-2956
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    An environmentally friendly protocol for oxidative halocyclization of tryptamine and tryptophol derivatives

    J. Xu and R. Tong, Green Chem., 2017, 19, 2952
    DOI: 10.1039/C7GC01341H

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