Issue 13, 2017

An environmentally friendly protocol for oxidative halocyclization of tryptamine and tryptophol derivatives

Abstract

An environmentally friendly and efficient protocol (KX/oxone) for oxidative halocyclization of tryptamine/tryptophol derivatives was developed and demonstrated with 28 examples and concise total synthesis of cyclotryptamine alkaloid protubonines A and B. The distinct advantage of this protocol over all previous methods is that no organic byproduct is generated from a halogenating agent or oxidant, thus greatly reducing the environmental impact of halocyclization and facilitating the post-reaction purification.

Graphical abstract: An environmentally friendly protocol for oxidative halocyclization of tryptamine and tryptophol derivatives

Supplementary files

Article information

Article type
Communication
Submitted
05 May 2017
Accepted
18 May 2017
First published
18 May 2017

Green Chem., 2017,19, 2952-2956

An environmentally friendly protocol for oxidative halocyclization of tryptamine and tryptophol derivatives

J. Xu and R. Tong, Green Chem., 2017, 19, 2952 DOI: 10.1039/C7GC01341H

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements