Fast, solvent-free and highly enantioselective fluorination of β-keto esters catalyzed by chiral copper complexes in a ball mill

Yifeng Wang; Haojiang Wang; Yidong Jiang; Cheng Zhang; Juanjuan Shao; Danqian Xu

doi:10.1039/C6GC03306G

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Fast, solvent-free and highly enantioselective fluorination of β-keto esters catalyzed by chiral copper complexes in a ball mill†

Yifeng Wang,

‡^a Haojiang Wang,‡^a Yidong Jiang,^a Cheng Zhang,^a Juanjuan Shao^a and Danqian Xu*^a

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* Corresponding authors

^a State Key Laboratory Breeding Base of Green Chemistry-Synthesis Technology, Key Laboratory of Green Pesticides and Cleaner Production Technology of Zhejiang Province, Zhejiang University of Technology, Hangzhou 310014, P. R. China
E-mail: chrc@zjut.edu.cn

Abstract

A fast and highly enantioselective fluorination of β-keto esters catalyzed by diphenylamine linked bis(oxazoline)-Cu(OTf)₂ complexes under solvent-free conditions has been developed using a planetary ball mill. High yields, high enantioselectivities and shorter reaction times were achieved with low catalyst loading.

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Article information

DOI: https://doi.org/10.1039/C6GC03306G
Article type: Communication
Submitted: 01 Dec 2016
Accepted: 09 Mar 2017
First published: 10 Mar 2017

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Green Chem., 2017,19, 1674-1677

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Fast, solvent-free and highly enantioselective fluorination of β-keto esters catalyzed by chiral copper complexes in a ball mill

Y. Wang, H. Wang, Y. Jiang, C. Zhang, J. Shao and D. Xu, Green Chem., 2017, 19, 1674 DOI: 10.1039/C6GC03306G

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Green Chemistry

Fast, solvent-free and highly enantioselective fluorination of β-keto esters catalyzed by chiral copper complexes in a ball mill†

Abstract

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Fast, solvent-free and highly enantioselective fluorination of β-keto esters catalyzed by chiral copper complexes in a ball mill

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