Directed alkynylation of unactivated C(sp3)–H bonds with ethynylbenziodoxolones mediated by DTBP

Zhi-Fei Cheng; Yi-Si Feng; Chun Rong; Tao Xu; Peng-Fei Wang; Jun Xu; Jian-Jun Dai; Hua-Jian Xu

doi:10.1039/C6GC01336H

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Directed alkynylation of unactivated C(sp³)–H bonds with ethynylbenziodoxolones mediated by DTBP†

Zhi-Fei Cheng,^a Yi-Si Feng,*^abc Chun Rong,^a Tao Xu,^a Peng-Fei Wang,^a Jun Xu,^a Jian-Jun Dai^a and Hua-Jian Xu*^abc

Author affiliations

* Corresponding authors

^a School of Chemistry and Chemical Engineering, School of Biological and Medical Engineering, Hefei University of Technology, Hefei 230009, P. R. China

^b Anhui Key Laboratory of Controllable Chemical Reaction and Material Chemical Engineering, Hefei 230009, P. R. China
E-mail: hjxu@hfut.edu.cn
Fax: (+86)-551-62904405

^c Anhui Provincial Laboratory of Heterocyclic Chemistry, Maanshan 243110, China

Abstract

A general and efficient method for the direct alkynylation of unactivated C(sp³)–H bonds under metal-free conditions is described. The reaction performs smoothly under mild conditions and shows excellent functional-group tolerance. Initial mechanistic investigation indicates that the reaction may involve a radical pathway.

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Article information

DOI: https://doi.org/10.1039/C6GC01336H
Article type: Communication
Submitted: 15 May 2016
Accepted: 24 Jun 2016
First published: 27 Jun 2016

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Green Chem., 2016,18, 4185-4188

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Directed alkynylation of unactivated C(sp³)–H bonds with ethynylbenziodoxolones mediated by DTBP

Z. Cheng, Y. Feng, C. Rong, T. Xu, P. Wang, J. Xu, J. Dai and H. Xu, Green Chem., 2016, 18, 4185 DOI: 10.1039/C6GC01336H

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