Sulfination of alcohols with sodium sulfinates promoted by BF3·OEt2: an unexpected access

Mingming Huang; Liangzhen Hu; Hang Shen; Qing Liu; Muhammad Ijaz Hussain; Jing Pan; Yan Xiong

doi:10.1039/C5GC02846A

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Sulfination of alcohols with sodium sulfinates promoted by BF₃·OEt₂: an unexpected access†

Mingming Huang,^a Liangzhen Hu,^a Hang Shen,^a Qing Liu,^a Muhammad Ijaz Hussain,^a Jing Pan^a and Yan Xiong*^ab

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* Corresponding authors

^a School of Chemistry and Chemical Engineering, Chongqing University, Chongqing 400030, China
E-mail: xiong@cqu.edu.cn

^b State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, China

Abstract

A BF₃·OEt₂-promoted direct substitution of various alcohols with sodium sulfinates affording sulfinates under mild conditions has been developed. Further reaction of the hydroxysteroids achieves the highly complex sulfinates in good yields, which are two potential pharmacophores routinely encountered in drug discovery.

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Article information

DOI: https://doi.org/10.1039/C5GC02846A
Article type: Communication
Submitted: 28 Nov 2015
Accepted: 11 Jan 2016
First published: 12 Jan 2016

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Green Chem., 2016,18, 1874-1879

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Sulfination of alcohols with sodium sulfinates promoted by BF₃·OEt₂: an unexpected access

M. Huang, L. Hu, H. Shen, Q. Liu, M. I. Hussain, J. Pan and Y. Xiong, Green Chem., 2016, 18, 1874 DOI: 10.1039/C5GC02846A

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