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Issue 3, 2015
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Micellar promoted multi-component synthesis of 1,2,3-triazoles in water at room temperature

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Abstract

Micellar media in water provide a simple and efficient environment favoring the multi-component synthesis of 1,2,3-triazoles from organic bromides, sodium azide and terminal alkynes in the presence of [Cu(IMes)Cl] 1 catalyst at room temperature within a few hours. The micellar medium favors both the in situ formation of the organic azide and its metal promoted cycloaddition with the alkyne.

Graphical abstract: Micellar promoted multi-component synthesis of 1,2,3-triazoles in water at room temperature

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Publication details

The article was received on 17 Nov 2014, accepted on 11 Jan 2015 and first published on 13 Jan 2015


Article type: Communication
DOI: 10.1039/C4GC02248C
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Citation: Green Chem., 2015,17, 1414-1422
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    Micellar promoted multi-component synthesis of 1,2,3-triazoles in water at room temperature

    E. Tasca, G. La Sorella, L. Sperni, G. Strukul and A. Scarso, Green Chem., 2015, 17, 1414
    DOI: 10.1039/C4GC02248C

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