Issue 2, 2015

Overcoming barriers to green chemistry in the pharmaceutical industry – the Green Aspiration Level™ concept

Abstract

“Green chemistry” refers to the promotion of safe, sustainable, and waste-minimizing chemical processes. The proliferation of green chemistry metrics without any clear consensus on industry standards is a significant barrier to the adoption of green chemistry within the pharmaceutical industry. We propose the Green Aspiration Level™ (GAL) concept as a novel process performance metric that quantifies the environmental impact of producing a specific pharmaceutical agent while taking into account the complexity of the ideal synthetic process for producing the target molecule. Application of the GAL metric will make possible for the first time an assessment of relative greenness of a process, in terms of waste, versus industry standards for the production process of any pharmaceutical. Our recommendations also include a simple methodology for defining process starting points, which is an important aspect of standardizing measurement to ensure that Relative Process Greenness (RPG) comparisons are meaningful. We demonstrate our methodology using Pfizer's Viagra™ process as an example, and outline aspiration level opportunities for industry and government to dismantle green chemistry barriers.

Graphical abstract: Overcoming barriers to green chemistry in the pharmaceutical industry – the Green Aspiration Level™ concept

Supplementary files

Article information

Article type
Perspective
Submitted
12 Aug 2014
Accepted
03 Nov 2014
First published
19 Nov 2014

Green Chem., 2015,17, 752-768

Author version available

Overcoming barriers to green chemistry in the pharmaceutical industry – the Green Aspiration Level™ concept

F. Roschangar, R. A. Sheldon and C. H. Senanayake, Green Chem., 2015, 17, 752 DOI: 10.1039/C4GC01563K

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