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Issue 10, 2013
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Bridging racemic lactate esters with stereoselective polylactic acid using commercial lipase catalysis

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Abstract

A productive and enantioselective hydrolysis of racemic mixtures of lactate esters with commercial Candida rugosa lipase was performed. This step contributes to a novel envisioned route for stereoselective PLA production by combining recent chemocatalytic developments with this biocatalytic contribution, foreseeing two separate L- and D-lactate enantiomer streams. A study of the hydrolysis kinetics identified an unexpected rate determining step at the origin of an unprecedented ester reactivity order.

Graphical abstract: Bridging racemic lactate esters with stereoselective polylactic acid using commercial lipase catalysis

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Publication details

The article was received on 22 Jul 2013, accepted on 13 Aug 2013 and first published on 14 Aug 2013


Article type: Paper
DOI: 10.1039/C3GC41457D
Citation: Green Chem., 2013,15, 2817-2824
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    Bridging racemic lactate esters with stereoselective polylactic acid using commercial lipase catalysis

    P. Van Wouwe, M. Dusselier, A. Basiç and B. F. Sels, Green Chem., 2013, 15, 2817
    DOI: 10.1039/C3GC41457D

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