An eco-benign and highly efficient access to 3-heterocyclic-substituted isoindolinones in ammonia water†
Abstract
A highly efficient three-component reaction of 2-formyl benzoic acid, ammonia and 4-hydroxycoumarin or indole in water was developed. With this highly environmentally benign protocol, a series of isoindolinone derivatives were efficiently produced in good to excellent yields.