Issue 11, 2012
From the journal:

Green Chemistry

A convenient guide to help select replacement solvents for dichloromethane in chromatography†

Joshua P. Taygerly,*a   Larry M. Miller,b   Alicia Yeec  and  Emily A. Peterson*d  

* Corresponding authors

a Medicinal Chemistry, Amgen Inc., 1120 Veterans Blvd., South San Francisco, CA 94080, USA
E-mail: taygerly@amgen.com
Tel: +1-650-244-2370

b Discovery Analytical Sciences, Medicinal Chemistry, Amgen Inc., 360 Binney St., Cambridge, MA 02142, USA
E-mail: millerl@amgen.com
Tel: +1-617-444-5008

c Northeastern University Boston, MA 12115, USA
E-mail: yee.ali@husky.neu.edu

d Medicinal Chemistry, Amgen Inc., 360 Binney St., Cambridge, MA 02142, USA
E-mail: epeterso@amgen.com
Fax: +1-617-621-3907
Tel: +1-617-444-5027

Abstract

One of the largest contributors to chlorinated solvent waste in medicinal chemistry is chromatography. A set of “drug-like” compounds was employed to compare the relative eluting strengths of greener solvent systems. Disclosed herein is an experimentally-derived solvent selection guide to aid chemists in choosing greener solvents for chromatographic purification, with a particular focus on reducing dichloromethane usage.

Graphical abstract: A convenient guide to help select replacement solvents for dichloromethane in chromatography

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Article information

DOI
https://doi.org/10.1039/C2GC36064K
Article type
Paper
Submitted
10 Jul 2012
Accepted
20 Aug 2012
First published
20 Aug 2012

Green Chem., 2012,14, 3020-3025

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A convenient guide to help select replacement solvents for dichloromethane in chromatography

J. P. Taygerly, L. M. Miller, A. Yee and E. A. Peterson, Green Chem., 2012, 14, 3020 DOI: 10.1039/C2GC36064K

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