TBHP/I2-promoted oxidative coupling of acetophenones with amines at room temperature under metal-free and solvent-free conditions for the synthesis of α-ketoamides

Xiaobin Zhang; Lei Wang

doi:10.1039/C2GC35489F

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TBHP/I₂-promoted oxidative coupling of acetophenones with amines at room temperature under metal-free and solvent-free conditions for the synthesis of α-ketoamides†

Xiaobin Zhang^a and Lei Wang*^ab

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* Corresponding authors

^a Department of Chemistry, Huaibei Normal University, Huaibei, Anhui 235000, P.R. China
E-mail: leiwang@chnu.edu.cn
Fax: +86-561-309-0518
Tel: +86-561-380-2069

^b State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, P.R. China

Abstract

A novel and efficient TBHP/I₂-promoted oxidative coupling reaction of acetophenones with amines for the synthesis of α-ketoamides has been developed. The reactions proceeded smoothly at room temperature under metal-free and solvent-free conditions and generated the corresponding products in good yields.

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Article information

DOI: https://doi.org/10.1039/C2GC35489F
Article type: Communication
Submitted: 02 Apr 2012
Accepted: 25 May 2012
First published: 28 May 2012

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Green Chem., 2012,14, 2141-2145

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TBHP/I₂-promoted oxidative coupling of acetophenones with amines at room temperature under metal-free and solvent-free conditions for the synthesis of α-ketoamides

X. Zhang and L. Wang, Green Chem., 2012, 14, 2141 DOI: 10.1039/C2GC35489F

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