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Issue 3, 2012
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Thiamine hydrochloride (VB1): an efficient promoter for the one-pot synthesis of benzo[4,5]imidazo[1,2-a]pyrimidine and [1,2,4]triazolo[1,5-a]pyrimidine derivatives in water medium

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Abstract

A straightforward and general method has been developed for the synthesis of benzo[4,5]imidazo[1,2-a]pyrimidine and [1,2,4]triazolo[1,5-a]pyrimidine derivatives by simply combining 2-aminobenzimidazole or 3-amino-1,2,4-triazole, aldehyde, and β-dicarbonyl compound in the presence of a catalytic amount of thiamine hydrochloride (VB1). The advantages of this method are the use of an inexpensive and readily available catalyst, easy workup, improved yields, and the use of water as the solvent that is considered to be relatively environmentally benign.

Graphical abstract: Thiamine hydrochloride (VB1): an efficient promoter for the one-pot synthesis of benzo[4,5]imidazo[1,2-a]pyrimidine and [1,2,4]triazolo[1,5-a]pyrimidine derivatives in water medium

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Publication details

The article was received on 23 Nov 2011, accepted on 11 Jan 2012, published on 10 Feb 2012 and first published online on 10 Feb 2012


Article type: Paper
DOI: 10.1039/C2GC16499J
Citation: Green Chem., 2012,14, 840-846
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    Thiamine hydrochloride (VB1): an efficient promoter for the one-pot synthesis of benzo[4,5]imidazo[1,2-a]pyrimidine and [1,2,4]triazolo[1,5-a]pyrimidine derivatives in water medium

    J. Liu, M. Lei and L. Hu, Green Chem., 2012, 14, 840
    DOI: 10.1039/C2GC16499J

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