Thiamine hydrochloride (VB1): an efficient promoter for the one-pot synthesis of benzo[4,5]imidazo[1,2-a]pyrimidine and [1,2,4]triazolo[1,5-a]pyrimidine derivatives in water medium

Junhua Liu; Min Lei; Lihong Hu

doi:10.1039/C2GC16499J

Thiamine hydrochloride (VB₁): an efficient promoter for the one-pot synthesis of benzo[4,5]imidazo[1,2-a]pyrimidine and [1,2,4]triazolo[1,5-a]pyrimidine derivatives in water medium

Junhua Liu,^a Min Lei*^b and Lihong Hu*^a^b

Author affiliations

* Corresponding authors

^a School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, P. R. China

^b Shanghai Institute of Materia Medica, Shanghai, P. R. China
E-mail: mlei@mail.shcnc.ac.cn, simmhulh@mail.shcnc.ac.cn
Fax: +86 20231965
Tel: +86 20231965

Abstract

A straightforward and general method has been developed for the synthesis of benzo[4,5]imidazo[1,2-a]pyrimidine and [1,2,4]triazolo[1,5-a]pyrimidine derivatives by simply combining 2-aminobenzimidazole or 3-amino-1,2,4-triazole, aldehyde, and β-dicarbonyl compound in the presence of a catalytic amount of thiamine hydrochloride (VB₁). The advantages of this method are the use of an inexpensive and readily available catalyst, easy workup, improved yields, and the use of water as the solvent that is considered to be relatively environmentally benign.

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Publication details

The article was received on 23 Nov 2011, accepted on 11 Jan 2012 and first published on 10 Feb 2012

Article type: Paper

DOI: 10.1039/C2GC16499J

Citation: Green Chem., 2012,14, 840-846

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Thiamine hydrochloride (VB₁): an efficient promoter for the one-pot synthesis of benzo[4,5]imidazo[1,2-a]pyrimidine and [1,2,4]triazolo[1,5-a]pyrimidine derivatives in water medium

J. Liu, M. Lei and L. Hu, Green Chem., 2012, 14, 840
DOI: 10.1039/C2GC16499J
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Green Chemistry

Thiamine hydrochloride (VB₁): an efficient promoter for the one-pot synthesis of benzo[4,5]imidazo[1,2-a]pyrimidine and [1,2,4]triazolo[1,5-a]pyrimidine derivatives in water medium

Abstract

Supplementary files

Publication details

Thiamine hydrochloride (VB₁): an efficient promoter for the one-pot synthesis of benzo[4,5]imidazo[1,2-a]pyrimidine and [1,2,4]triazolo[1,5-a]pyrimidine derivatives in water medium

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