Issue 3, 2012

Solvent-free and efficient synthesis of imidazo[1,2-a]pyridine derivatives via a one-pot three-component reaction

Abstract

A green and highly efficient method for the regioselective synthesis of imidazo[1,2-a]pyridine derivatives has been developed by annulation of heterocyclic ketene aminals (HKAs) and β-oxodithioesters (ODEs) as building blocks with aldehydes under solvent-free conditions using Et3N as the catalyst. The present green synthesis shows fascinating properties such as high regioselectivity, concise one-pot methodology, short reaction times, easy purification and avoids the use of transition metals. This methodology provides an alternative approach for easy access to highly substituted imidazo[1,2-a]pyridines in good yields.

Graphical abstract: Solvent-free and efficient synthesis of imidazo[1,2-a]pyridine derivatives via a one-pot three-component reaction

Supplementary files

Article information

Article type
Paper
Submitted
03 Nov 2011
Accepted
06 Dec 2011
First published
13 Jan 2012

Green Chem., 2012,14, 707-716

Solvent-free and efficient synthesis of imidazo[1,2-a]pyridine derivatives via a one-pot three-component reaction

L. Wen, Z. Li, M. Li and H. Cao, Green Chem., 2012, 14, 707 DOI: 10.1039/C2GC16388H

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements