Issue 12, 2011
From the journal:

Green Chemistry

An efficient and expeditious Fmoc protection of amines and amino acids in aqueous media†

Manoj B. Gawande*a  and  Paula S. Branco*a  

* Corresponding authors

a REQUIMTE, Departamento de Química, Faculdade de Ciências e Tecnologia, FCT, Universidade Nova de Lisboa, Portugal
E-mail: mbgawande@yahoo.co.in, psb@dq.fct.unl.pt

Abstract

A new and environmentally friendly Fmoc protection of a variety of aliphatic and aromatic amines, amino acids, amino alcohols and amino phenols is reported in aqueous media under mild and catalyst-free conditions. The reaction proved to be chemoselective in presence of ambident nucleophiles.

Graphical abstract: An efficient and expeditious Fmoc protection of amines and amino acids in aqueous media

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Article information

DOI
https://doi.org/10.1039/C1GC15868F
Article type
Communication
Submitted
18 Jul 2011
Accepted
23 Sep 2011
First published
17 Oct 2011

Green Chem., 2011,13, 3355-3359

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An efficient and expeditious Fmoc protection of amines and amino acids in aqueous media

M. B. Gawande and P. S. Branco, Green Chem., 2011, 13, 3355 DOI: 10.1039/C1GC15868F

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