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Issue 10, 2011
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Protective opening of epoxide using pivaloyl halides under catalyst-free conditions

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Abstract

An efficient and environmentally benign protocol for protective opening of epoxide (POE) with pivaloyl halides in solvent-free conditions and in aqueous media under catalyst-free conditions has been developed. The green reaction conditions, simple work-up procedures, high yields and broad scope of the reaction illustrate the good synthetic utility of this method. The key advantages of the reaction are regioselectivity and reconvertability of products into their prior epoxides in the presence of mild reaction conditions.

Graphical abstract: Protective opening of epoxide using pivaloyl halides under catalyst-free conditions

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Publication details

The article was received on 04 May 2011, accepted on 25 Jul 2011 and first published on 22 Aug 2011


Article type: Communication
DOI: 10.1039/C1GC15506G
Citation: Green Chem., 2011,13, 2704-2707
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    Protective opening of epoxide using pivaloyl halides under catalyst-free conditions

    C. B. Rao, D. C. Rao, M. Venkateswara and Y. Venkateswarlu, Green Chem., 2011, 13, 2704
    DOI: 10.1039/C1GC15506G

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