Issue 2, 2011
From the journal:

Green Chemistry

Silver-catalyzed intramolecular hydroamination of alkynes in aqueous media: efficient and regioselective synthesis for fused benzimidazoles†

Xu Zhang,ab   Yu Zhou,b   Hengshuai Wang,b   Diliang Guo,ab   Deju Ye,b   Yungen Xu,a   Hualiang Jiangb  and  Hong Liu*ab  

* Corresponding authors

a Department of Medicinal Chemistry, China Pharmaceutical University, 24 Tong jia Xiang, Nanjing, P. R. China

b State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai, China
E-mail: hliu@mail.shcnc.ac.cn
Fax: +86 21-50807042
Tel: +86 21-50807042

Abstract

A simple, convenient and green synthetic approach to diverse fused tricyclic benzimidazoles has been developed by Ag(I) complex catalyzed intramolecular hydroamination under the classic method or by microwave irradiation in water. This strategy presents an operationally simple and environmentally friendly transformation, in which various substituted benzimidazoles facilitated efficient cyclization.

Graphical abstract: Silver-catalyzed intramolecular hydroamination of alkynes in aqueous media: efficient and regioselective synthesis for fused benzimidazoles

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Article information

DOI
https://doi.org/10.1039/C0GC00668H
Article type
Paper
Submitted
11 Oct 2010
Accepted
01 Dec 2010
First published
23 Dec 2010

Green Chem., 2011,13, 397-405

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Silver-catalyzed intramolecular hydroamination of alkynes in aqueous media: efficient and regioselective synthesis for fused benzimidazoles

X. Zhang, Y. Zhou, H. Wang, D. Guo, D. Ye, Y. Xu, H. Jiang and H. Liu, Green Chem., 2011, 13, 397 DOI: 10.1039/C0GC00668H

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