Issue 1, 2011
From the journal:

Green Chemistry

Catalyst-free and catalytic Friedel–Crafts alkylations of indoles in Solkane® 365mfc, an environmentally benign alternative solvent†

Xiu-Hua Xu,a   Akihiro Kusuda,a   Etsuko Tokunagaa  and  Norio Shibata*a  

* Corresponding authors

a Department of Frontier Materials, Graduate School of Engineering, Nagoya Institute of Technology, Gokiso, Showa-ku, Nagoya, Japan
E-mail: nozshiba@nitech.ac.jp
Fax: +81 52-735-5442

Abstract

Solkane® 365mfc is a proven environmentally benign alternative solvent for catalyst-free Friedel–Crafts (F–C) alkylations of indoles with trifluoropyruvate and glyoxylate. Their enantioselective variants are also achieved by virtue of the high-affinity of fluorous cinchona alkaloids catalysts to Solkane® 365mfc to provide F–C adducts in excellent yields with good to excellent ees (up to 96% ee).

Graphical abstract: Catalyst-free and catalytic Friedel–Crafts alkylations of indoles in Solkane® 365mfc, an environmentally benign alternative solvent

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Article information

DOI
https://doi.org/10.1039/C0GC00619J
Article type
Communication
Submitted
29 Sep 2010
Accepted
08 Nov 2010
First published
19 Nov 2010

Green Chem., 2011,13, 46-50

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Catalyst-free and catalytic Friedel–Crafts alkylations of indoles in Solkane® 365mfc, an environmentally benign alternative solvent

X. Xu, A. Kusuda, E. Tokunaga and N. Shibata, Green Chem., 2011, 13, 46 DOI: 10.1039/C0GC00619J

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