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Issue 4, 2011
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Efficient and ‘green’ microwave-assisted synthesis of haloalkylphosphonates via the Michaelis–Arbuzov reaction

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Abstract

This paper deals with a novel, efficient and environmentally friendly synthesis of dialkyl haloalkylphosphonates via a microwave-assisted Michaelis–Arbuzov reaction. The approach is solventless, requires only one equivalent of each of the starting compounds, and provides high yields of pure products from which the impurities are easy to remove. The process has been optimised for batch and flow reactors and is especially profitable for the production of key intermediates in synthesis of Ethephon or acyclic nucleoside phosphonates such as adefovir, tenofovir, and cidofovir.

Graphical abstract: Efficient and ‘green’ microwave-assisted synthesis of haloalkylphosphonates via the Michaelis–Arbuzov reaction

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Publication details

The article was received on 01 Sep 2010, accepted on 05 Jan 2011 and first published on 07 Feb 2011


Article type: Paper
DOI: 10.1039/C0GC00509F
Citation: Green Chem., 2011,13, 882-888
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    Efficient and ‘green’ microwave-assisted synthesis of haloalkylphosphonates via the Michaelis–Arbuzov reaction

    P. Jansa, A. Holý, M. Dračinský, O. Baszczyňski, M. Česnek and Z. Janeba, Green Chem., 2011, 13, 882
    DOI: 10.1039/C0GC00509F

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