Issue 12, 2010
From the journal:

Green Chemistry

Ionic liquids for enhancing the enantioselectivity of isolated BVMO-catalysed oxidations†‡

Cristina Rodríguez,a   Gonzalo de Gonzalo,b   Marco W. Fraaijeb  and  Vicente Gotor*a  

* Corresponding authors

a Departamento de Química Orgánica e Inorgánica, Instituto Universitario de Biotecnología de Asturias, Universidad de Oviedo, C/Julián Clavería 8, Oviedo, Spain
E-mail: vgs@fq.uniovi.es
Fax: +34 985 103448
Tel: +34 985 103448

b Laboratory of Biochemistry, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Nijenborgh 4, Groningen, The Netherlands

Abstract

The present study describes the first-time usage of an isolated thermostable Baeyer–Villiger monooxygenase (phenylacetone monooxygenase, PAMO) in the presence of ionic liquids. The stability, activity and selectivity of PAMO as an oxidative enzyme in the presence of different ionic liquids were studied. This revealed that the addition of some specific ionic liquids, such Ammoeng™ 102 and [bmim]MeSO4, can significantly enhance the E-value in the oxidation of racemic benzylketones. Moreover, the use of ionic liquids increases the optimal substrate concentration for performing Baeyer–Villiger oxidation, thereby extending the biocatalytic repertoire of PAMO for synthetic applications.

Graphical abstract: Ionic liquids for enhancing the enantioselectivity of isolated BVMO-catalysed oxidations

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Article information

DOI
https://doi.org/10.1039/C0GC00560F
Article type
Paper
Submitted
16 Sep 2010
Accepted
22 Oct 2010
First published
12 Nov 2010

Green Chem., 2010,12, 2255-2260

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Ionic liquids for enhancing the enantioselectivity of isolated BVMO-catalysed oxidations

C. Rodríguez, G. de Gonzalo, M. W. Fraaije and V. Gotor, Green Chem., 2010, 12, 2255 DOI: 10.1039/C0GC00560F

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