Jump to main content
Jump to site search

Issue 7, 2010
Previous Article Next Article

Development of safe and scalable continuous-flow methods for palladium-catalyzed aerobic oxidation reactions

Author affiliations

Abstract

The synthetic scope and utility of Pd-catalyzed aerobic oxidation reactions has advanced significantly over the past decade, and these reactions have the potential to address important green-chemistry challenges in the pharmaceutical industry. This potential has not been realized, however, because safety concerns and process constraints hinder large-scale applications of this chemistry. These limitations are addressed by the development of a continuous-flow tube reactor, which has been demonstrated on several scales in the aerobic oxidation of alcohols. Use of a dilute oxygen gas source (8% O2 in N2) ensures that the oxygen/organic mixture never enters the explosive regime, and efficient gas-liquid mixing in the reactor minimizes decomposition of the homogeneous catalyst into inactive Pd metal. These results provide the basis for large-scale implementation of palladium-catalyzed (and other) aerobic oxidation reactions for pharmaceutical synthesis.

Graphical abstract: Development of safe and scalable continuous-flow methods for palladium-catalyzed aerobic oxidation reactions

Back to tab navigation

Supplementary files

Publication details

The article was received on 14 May 2010, accepted on 28 May 2010 and first published on 16 Jun 2010


Article type: Paper
DOI: 10.1039/C0GC00106F
Citation: Green Chem., 2010,12, 1180-1186
  •   Request permissions

    Development of safe and scalable continuous-flow methods for palladium-catalyzed aerobic oxidation reactions

    X. Ye, M. D. Johnson, T. Diao, M. H. Yates and S. S. Stahl, Green Chem., 2010, 12, 1180
    DOI: 10.1039/C0GC00106F

Search articles by author

Spotlight

Advertisements