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Issue 12, 2009
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Suzuki-Miyaura cross-coupling catalyzed by protein-stabilized palladium nanoparticles under aerobic conditions in water: application to a one-pot chemoenzymatic enantioselective synthesis of chiral biaryl alcohols

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Abstract

The preparation of palladium nanoparticles stabilized primarily within the protein cavity of a highly thermostable Dps protein (DNA binding protein from starved cells) and the use of this precatalyst system in Suzuki-Miyaura cross-coupling reactions under aerobic conditions in water is described, as well as a two-step one-pot Suzuki-Miyaura cross-coupling followed by an enantioselective enzyme-catalyzed reduction to form chiral biaryl alcohols.

Graphical abstract: Suzuki-Miyaura cross-coupling catalyzed by protein-stabilized palladium nanoparticles under aerobic conditions in water: application to a one-pot chemoenzymatic enantioselective synthesis of chiral biaryl alcohols

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Publication details

The article was received on 27 Jul 2009, accepted on 15 Sep 2009 and first published on 30 Sep 2009


Article type: Communication
DOI: 10.1039/B915184B
Citation: Green Chem., 2009,11, 1929-1932
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    Suzuki-Miyaura cross-coupling catalyzed by protein-stabilized palladium nanoparticles under aerobic conditions in water: application to a one-pot chemoenzymatic enantioselective synthesis of chiral biaryl alcohols

    A. Prastaro, P. Ceci, E. Chiancone, A. Boffi, R. Cirilli, M. Colone, G. Fabrizi, A. Stringaro and S. Cacchi, Green Chem., 2009, 11, 1929
    DOI: 10.1039/B915184B

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