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Issue 6, 2009
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Synthesis of novel 6-[N,N-bis(2-hydroxyethyl)amino]purine nucleosides under microwave irradiation in neat water

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Abstract

Novel 6-[N,N-bis(2-hydroxyethyl)amino]purine nucleosides were prepared in one step by nucleophilic substitution reaction of 6-choloropurine nucleosides with diethanolamine. Shorter reaction times and higher yields were achieved under microwave irradiation conditions in neat water.

Graphical abstract: Synthesis of novel 6-[N,N-bis(2-hydroxyethyl)amino]purine nucleosides under microwave irradiation in neat water

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Publication details

The article was received on 02 Feb 2009, accepted on 06 Mar 2009 and first published on 16 Mar 2009


Article type: Communication
DOI: 10.1039/B902025J
Citation: Green Chem., 2009,11, 760-762
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    Synthesis of novel 6-[N,N-bis(2-hydroxyethyl)amino]purine nucleosides under microwave irradiation in neat water

    G. Qu, J. Wu, Y. Wu, F. Zhang and H. Guo, Green Chem., 2009, 11, 760
    DOI: 10.1039/B902025J

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