Issue 6, 2009

N-alkylation of N-heterocyclic ionic liquid precursors in ionic liquids

Abstract

The room temperature ionic liquids [BMIM][PF6] and [P14][Tf2N] in conjunction with KOH are superior reaction media for the alkylation of the secondary amine 3-azabicyclo[3.2.2]nonane under mild conditions. The factors examined were alkyl halide chain length (C1 to C4) and halide identity (Cl, Br, I). The tertiary amine products are released from the reaction medium as a separate layer and can be isolated in good yields by simple decantation.

Graphical abstract: N-alkylation of N-heterocyclic ionic liquid precursors in ionic liquids

Article information

Article type
Paper
Submitted
07 Oct 2008
Accepted
23 Feb 2009
First published
12 Mar 2009

Green Chem., 2009,11, 804-809

N-alkylation of N-heterocyclic ionic liquid precursors in ionic liquids

T. Rüther, T. Ross, E. J. Mensforth and A. F. Hollenkamp, Green Chem., 2009, 11, 804 DOI: 10.1039/B817526H

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