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Issue 4, 2009
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N-phosphorylation of amino acids by trimetaphosphate in aqueous solution—learning from prebiotic synthesis

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Abstract

Inspired by a reactivity study between sodium trimetaphosphate (P3m) and amino acids in prebiotic chemistry, a one-step reaction with efficient purification procedure in aqueous media has been developed for the synthesis of N-phosphono-amino acids (NPAA). P3m was used to phosphorylate amino acids to NPAA with yields of 60∼91%. The by-products, inorganic polyphosphates, were recycled to regenerate the phosphorylation reagent P3m.

Graphical abstract: N-phosphorylation of amino acids by trimetaphosphate in aqueous solution—learning from prebiotic synthesis

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Publication details

The article was received on 06 Oct 2008, accepted on 19 Jan 2009 and first published on 17 Feb 2009


Article type: Paper
DOI: 10.1039/B817013D
Citation: Green Chem., 2009,11, 569-573
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    N-phosphorylation of amino acids by trimetaphosphate in aqueous solution—learning from prebiotic synthesis

    F. Ni, S. Sun, C. Huang and Y. Zhao, Green Chem., 2009, 11, 569
    DOI: 10.1039/B817013D

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