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Issue 6, 2008
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Efficient synthesis of disulfides by air oxidation of thiols under sonication

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Abstract

Alkyl, aryl and heteroaryl symmetrical disulfides can be easily obtained by heating the corresponding thiols for several hours at 80 °C with Et3N in DMF under atmospheric oxygen. These reactions are markedly accelerated by ultrasounds (few minutes at rt). Aromatic groups bearing electron donating and electron withdrawing groups, heteroaromatic, and alkyl thiols are analogously efficient affording disulfides in almost quantitative yields. Aminothiols and L-cysteine provide the corresponding disulfides without affecting the nitrogen function.

Graphical abstract: Efficient synthesis of disulfides by air oxidation of thiols under sonication

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Publication details

The article was received on 15 Jan 2008, accepted on 08 Apr 2008 and first published on 09 May 2008


Article type: Paper
DOI: 10.1039/B800705E
Citation: Green Chem., 2008,10, 706-711
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    Efficient synthesis of disulfides by air oxidation of thiols under sonication

    J. L. García Ruano, A. Parra and J. Alemán, Green Chem., 2008, 10, 706
    DOI: 10.1039/B800705E

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