Issue 10, 2005
From the journal:

Green Chemistry

Tertiary amines as highly efficient catalysts in the ring-opening reactions of epoxides with amines or thiols in H2O: expeditious approach to β-amino alcohols and β-aminothioethers

Jie Wu*ab  and  Hong-Guang Xiaa  

* Corresponding authors

a Department of Chemistry, Fudan University, 220 Handan Road, Shanghai, P. R. China
E-mail: jie_wu@fudan.edu.cn
Fax: +86 21 6510 2412
Tel: +86 21 5566 4619

b State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Road, Shanghai, P. R. China

Abstract

Ring-opening of epoxides with various amines or thiols catalyzed by DABCO (1,4-diazabicyclic[2,2,2]octane) or Et3N (1 mol%) in water afforded the corresponding products in good to excellent yields under mild reaction conditions.

Graphical abstract: Tertiary amines as highly efficient catalysts in the ring-opening reactions of epoxides with amines or thiols in H2O: expeditious approach to β-amino alcohols and β-aminothioethers

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Article information

DOI
https://doi.org/10.1039/B509288D
Article type
Communication
Submitted
30 Jun 2005
Accepted
19 Aug 2005
First published
31 Aug 2005

Green Chem., 2005,7, 708-710

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Tertiary amines as highly efficient catalysts in the ring-opening reactions of epoxides with amines or thiols in H2O: expeditious approach to β-amino alcohols and β-aminothioethers

J. Wu and H. Xia, Green Chem., 2005, 7, 708 DOI: 10.1039/B509288D

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