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Issue 1, 2012
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Protective effects of Allium paradoxum against gentamicin-induced nephrotoxicity in mice

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Abstract

Allium paradoxum (M.Bieb.) G. Don is a locally known vegetable and is utilized for preparation a variety of local foods in northern of Iran. This study was conducted to quantitatively evaluate the recovery effects of A. paradoxum on gentamicin-induced nephrotoxicity in mice. The curative effect of extracts from the aerial parts and bulbs of A. paradoxum against gentamicin-induced renotoxicity in mice was determined. Both extracts at the dose 200 mg kg−1 day−1 offered nephroprotective effect by change in the blood urea nitrogen and creatinine. No statistical difference could be obtained in serum creatinine and blood urea nitrogen of bulb-treated mice compared to normal mice. The result show that bulb extract at 200 mg kg−1 day−1 has better activity than aerial parts.

Graphical abstract: Protective effects of Allium paradoxum against gentamicin-induced nephrotoxicity in mice

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Publication details

The article was received on 22 Aug 2011, accepted on 15 Oct 2011 and first published on 28 Oct 2011


Article type: Communication
DOI: 10.1039/C1FO10173K
Citation: Food Funct., 2012,3, 28-29
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    Protective effects of Allium paradoxum against gentamicin-induced nephrotoxicity in mice

    S. F. Nabavi, S. M. Nabavi, A. H. Moghaddam, A. Naqinezhad, R. Bigdellou and S. Mohammadzadeh, Food Funct., 2012, 3, 28
    DOI: 10.1039/C1FO10173K

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