Volume 149, 2011

Multiphoton microscopy of transdermal quantum dot delivery using two photonpolymerization-fabricated polymer microneedles

Abstract

Due to their ability to serve as fluorophores and drug delivery vehicles, quantum dots are a powerful tool for theranostics-based clinical applications. In this study, microneedle devices for transdermal drug delivery were fabricated by means of two-photon polymerization of an acrylate-based polymer. We examined proliferation of cells on this polymer using neonatal human epidermal keratinocytes and human dermal fibroblasts. The microneedle device was used to inject quantum dots into porcine skin; imaging of the quantum dots was performed using multiphoton microscopy.

Article information

Article type
Paper
Submitted
18 May 2010
Accepted
22 Jun 2010
First published
23 Sep 2010

Faraday Discuss., 2011,149, 171-185

Multiphoton microscopy of transdermal quantum dot delivery using two photon polymerization-fabricated polymer microneedles

S. D. Gittard, P. R. Miller, R. D. Boehm, A. Ovsianikov, B. N. Chichkov, J. Heiser, J. Gordon, N. A. Monteiro-Riviere and R. J. Narayan, Faraday Discuss., 2011, 149, 171 DOI: 10.1039/C005374K

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements