Enhancement of the antiproliferative activity of [RuCp(PPh3)2(dmoPTA-1κP)]+via its coordination to one {CoCl2} unit: synthesis, crystal structure and properties of [RuCp(PPh3)2-μ-dmoPTA-1κP:2κ2N,N′-CoCl2](OTf)·0.25H2O

Abstract

Synthesis, characterization and the antiproliferative activity of a new bimetallic complex [RuCp(PPh₃)₂-μ-dmoPTA-1κP:2k²N,N′-CoCl₂]OTf·0.25H₂O are described. The stability of the complex was studied under air and N₂ atmospheres and in CDCl₃, DMSO, water and the cell culture medium, at room temperature and 40 °C. The complex showed an enhanced antiproliferative activity (up to six-fold) when compared with its parent complex [RuCp(PPh₃)₂(HdmoPTA)]²⁺ against human lung, cervix, breast, and colon solid tumor cell lines.