Dinuclear zinc(II) complexes containing (benzimidazol-2-yl)benzene that overcome drug resistance in hepatocellular carcinoma cells through induction of mitochondria fragmentation

Qiang Xie; Shenggui Liu; Xiaoling Li; Qiong Wu; Zuandi Luo; Xiaoyan Fu; Wenqiang Cao; Guoqiang Lan; Dan Li; Wenjie Zheng; Tianfeng Chen

doi:10.1039/C4DT00198B

Dinuclear zinc(ii) complexes containing (benzimidazol-2-yl)benzene that overcome drug resistance in hepatocellular carcinoma cells through induction of mitochondria fragmentation†

Qiang Xie,‡^ab Shenggui Liu,‡^ac Xiaoling Li,‡^a Qiong Wu,^a Zuandi Luo,^a Xiaoyan Fu,^a Wenqiang Cao,^a Guoqiang Lan,^a Dan Li,*^d Wenjie Zheng^a and Tianfeng Chen*^a

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* Corresponding authors

^a Department of Chemistry, Jinan University, Guangzhou 510632, China
E-mail: tchentf@jnu.edu.cn

^b Wu Jing Zong Dui Hospital of Guangdong Province, Guangzhou, China

^c Department of Chemistry Science and Technology, Zhanjiang Normal University, Zhanjiang 524048, P.R. China

^d Department of Chemistry, Shantou University, Guangdong 515063, China
E-mail: dli@stu.edu.cn

Abstract

Herein we demonstrated that dinuclear zinc complexes could overcome drug resistance in R-HepG2 drug resistance hepatocellular carcinoma cells through induction of mitochondria-mediated apoptosis or by triggering mitochondria fragmentation, depletion of the membrane potential and intracellular ATP levels.

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Dinuclear zinc(ii) complexes containing (benzimidazol-2-yl)benzene that overcome drug resistance in hepatocellular carcinoma cells through induction of mitochondria fragmentation†

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Dinuclear zinc(II) complexes containing (benzimidazol-2-yl)benzene that overcome drug resistance in hepatocellular carcinoma cells through induction of mitochondria fragmentation

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