Jump to main content
Jump to site search

Issue 46, 2012
Previous Article Next Article

Cyclization of RGD peptide sequences via the macrocyclic chelator DOTA for integrin imaging

Author affiliations

Abstract

Two bicyclic compounds containing Arg-Gly-Asp (RGD) motifs (RGDf and RGD) were synthesized by cyclizing the peptide sequence across the macrocyclic ring of DOTA via two non-adjacent carboxylate pendent arms. The Lu3+ or Cu2+ complexes of these compounds, c(DOTA-RGDf) and c(DOTA-RGD), showed a metal dependent affinity towards integrin αvβ3in vitro and the 177Lu3+ or 64Cu2+ labelled derivatives showed specific tumour uptake in MCF7 and U87MG tumour bearing mice.

Graphical abstract: Cyclization of RGD peptide sequences via the macrocyclic chelator DOTA for integrin imaging

Back to tab navigation
Please wait while Download options loads

Supplementary files

Publication details

The article was received on 08 Jul 2012, accepted on 01 Oct 2012 and first published on 22 Oct 2012


Article type: Communication
DOI: 10.1039/C2DT31493B
Citation: Dalton Trans., 2012,41, 14051-14054
  •   Request permissions

    Cyclization of RGD peptide sequences via the macrocyclic chelator DOTA for integrin imaging

    G. Hao, X. Sun, Q. N. Do, B. Ocampo-García, A. Vilchis-Juárez, G. Ferro-Flores and L. M. De León-Rodríguez, Dalton Trans., 2012, 41, 14051
    DOI: 10.1039/C2DT31493B

Search articles by author