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Issue 38, 2012
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Incorporation of triazole into a quinoline-rhodamine conjugate imparts iron(III) selective complexation permitting detection at nanomolar levels

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Abstract

Two new rhodamine based probes 1 and 2 for the detection of Fe3+ were synthesized and their selectivity towards Fe3+ ions in the presence of other competitive metal ions tested. The probe 1 formed a coloured complex with Fe3+ as well as Cu2+ ions and revealed the lack of adequate number of coordination sites for selective complexation with Fe3+. Incorporation of a triazole unit to the chelating moiety of 1 resulted in the probe 2, that displayed Fe3+ selective complex formation even in the presence of other competitive metal ions like Li+, Na+, K+, Cu2+, Mg2+, Ca2+, Sr2+, Cr3+, Mn2+, Fe2+, Co2+, Ni2+, Zn2+, Cd2+, Hg2+ and Pb2+. The observed limit of detection of Fe3+ ions (5 × 10−8 M) confirmed the very high sensitivity of 2. The excellent stability of 2 in physiological pH conditions, non-interference of amino acids, blood serum and bovine serum albumin (BSA) in the detection process, and the remarkable selectivity for Fe3+ ions permitted the use of 2 in the imaging of live fibroblast cells treated with Fe3+ ions.

Graphical abstract: Incorporation of triazole into a quinoline-rhodamine conjugate imparts iron(iii) selective complexation permitting detection at nanomolar levels

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Publication details

The article was received on 19 Jun 2012, accepted on 26 Jul 2012 and first published on 26 Jul 2012


Article type: Paper
DOI: 10.1039/C2DT31316B
Citation: Dalton Trans., 2012,41, 11753-11759
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    Incorporation of triazole into a quinoline-rhodamine conjugate imparts iron(III) selective complexation permitting detection at nanomolar levels

    N. R. Chereddy, S. Thennarasu and A. B. Mandal, Dalton Trans., 2012, 41, 11753
    DOI: 10.1039/C2DT31316B

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