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Issue 31, 2011
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Holo-Ni2+Helicobacter pylori NikR contains four square-planar nickel-binding sites at physiological pH

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Abstract

The crystal structure of Helicobacter pylori holo-NikR, a Ni2+-dependent transcription factor, determined at pH 7.3, shows four square-planar nickel-binding sites, involving one cysteinate and three histidine ligands. This observation reconciles previous inconsistencies among calorimetric data, structural information at non-physiological pH, and computational studies.

Graphical abstract: Holo-Ni2+Helicobacter pylori NikR contains four square-planar nickel-binding sites at physiological pH

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Publication details

The article was received on 25 Feb 2011, accepted on 16 Jun 2011 and first published on 04 Jul 2011


Article type: Communication
DOI: 10.1039/C1DT11107H
Citation: Dalton Trans., 2011,40, 7831-7833
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    Holo-Ni2+Helicobacter pylori NikR contains four square-planar nickel-binding sites at physiological pH

    S. Benini, M. Cianci and S. Ciurli, Dalton Trans., 2011, 40, 7831
    DOI: 10.1039/C1DT11107H

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