Issue 31, 2011
From the journal:

Dalton Transactions

Holo-Ni2+Helicobacter pylori NikR contains four square-planar nickel-binding sites at physiological pH†

Stefano Benini,a   Michele Ciancib  and  Stefano Ciurli*c  

* Corresponding authors

a Faculty of Science and Technology, Free University of Bolzano, Bolzano, Italy
E-mail: stefano.benini@unibz.it
Fax: +39 0471 017009
Tel: +39 0471 017128

b European Molecular Biology Laboratory c/o DESY, Hamburg, Germany
E-mail: m.cianci@embl-hamburg.de
Fax: +49 4089 902149
Tel: +49 4089 902110

c Laboratory of Bioinorganic Chemistry, University of Bologna, Bologna, Italy
E-mail: stefano.ciurli@unibo.it
Fax: +39 051 2096203
Tel: +39 051 2096204

Abstract

The crystal structure of Helicobacter pylori holo-NikR, a Ni2+-dependent transcription factor, determined at pH 7.3, shows four square-planar nickel-binding sites, involving one cysteinate and three histidine ligands. This observation reconciles previous inconsistencies among calorimetric data, structural information at non-physiological pH, and computational studies.

Graphical abstract: Holo-Ni2+Helicobacter pylori NikR contains four square-planar nickel-binding sites at physiological pH

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Article information

DOI
https://doi.org/10.1039/C1DT11107H
Article type
Communication
Submitted
25 Feb 2011
Accepted
16 Jun 2011
First published
04 Jul 2011

Dalton Trans., 2011,40, 7831-7833

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Holo-Ni2+Helicobacter pylori NikR contains four square-planar nickel-binding sites at physiological pH

S. Benini, M. Cianci and S. Ciurli, Dalton Trans., 2011, 40, 7831 DOI: 10.1039/C1DT11107H

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