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Issue 12, 2011
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Absorption of 10-hydroxycamptothecin on Fe3O4 magnetite nanoparticles with layer-by-layer self-assembly and drug release response

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Abstract

In this paper, the structural and zeta potential properties of 10-hydroxycamptothecin (HCPT) were investigated by FT-IR and zeta potential analyzer under different pH. The anticancer drug HCPT as a model drug was used to prepare a high-performance and relatively easy-to-fabricate system on Fe3O4 magnetite nanoparticles by using a polystyrene sulfonate (PSS) and HCPT interlayer self-assembly method. The results obtained from FT-IR and XRD confirmed that HCPT was molecularly dispersed into the nanoparticles. The method holds not only environment-friendly characteristics and the ability to mimic the self-organization process in biological systems but also greatly decreases adjuvant polymers. In addition, the system has an ideal drug payload for the delivery of insoluble HCPTs.

Graphical abstract: Absorption of 10-hydroxycamptothecin on Fe3O4 magnetite nanoparticles with layer-by-layer self-assembly and drug release response

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Publication details

The article was received on 23 Oct 2010, accepted on 13 Jan 2011 and first published on 17 Feb 2011


Article type: Paper
DOI: 10.1039/C0DT01455A
Citation: Dalton Trans., 2011,40, 3039-3046
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    Absorption of 10-hydroxycamptothecin on Fe3O4 magnetite nanoparticles with layer-by-layer self-assembly and drug release response

    X. M. Guo, B. Guo, Q. Zhang and X. Sun, Dalton Trans., 2011, 40, 3039
    DOI: 10.1039/C0DT01455A

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