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Issue 23, 2011
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Multimodal radio- (PET/SPECT) and fluorescence imaging agents based on metallo-radioisotopes: current applications and prospects for development of new agents

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Abstract

This perspective focuses on complexes of radioactive metal ions applied in multimodal radio- and optical imaging. The application of metal ions in radioimaging techniques such as Positron Emission Tomography (PET) and Single Photon Emission Computed Tomography (SPECT) has advantages over lighter nuclei in terms of half-life, but there are particular issues related to their speciation (particularly leaching from complexes) and with the combination of certain ions with fluorescent systems. The basic coordination chemistry of the ions involved and issues relating to biological conditions and their compatibility with optical imaging techniques are reviewed, the current literature presented in context, and the prospect of exploiting the intrinsic luminescence of certain metal–ligand complexes is discussed.

Graphical abstract: Multimodal radio- (PET/SPECT) and fluorescence imaging agents based on metallo-radioisotopes: current applications and prospects for development of new agents

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Publication details

The article was received on 15 Oct 2010, accepted on 09 Dec 2010 and first published on 12 Jan 2011


Article type: Perspective
DOI: 10.1039/C0DT01398F
Citation: Dalton Trans., 2011,40, 6129-6143
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    Multimodal radio- (PET/SPECT) and fluorescence imaging agents based on metallo-radioisotopes: current applications and prospects for development of new agents

    F. L. Thorp-Greenwood and M. P. Coogan, Dalton Trans., 2011, 40, 6129
    DOI: 10.1039/C0DT01398F

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