Issue 47, 2010
From the journal:

Dalton Transactions

An androgenic steroid delivery vector that imparts activity to a non-conventional platinum(ii) metallo-drug†

Martin Huxley,‡a   Carlos Sanchez-Cano,‡b   Michael J. Browning,a   Carmen Navarro-Ranninger,c   Adoracion G. Quiroga,*ac   Alison Rodger*a  and  Michael J. Hannon*ab  

* Corresponding authors

a Department of Chemistry, University of Warwick, Coventry, UK
E-mail: a.rodger@warwick.ac.uk

b School of Chemistry, University of Birmingham, Birmingham, UK
E-mail: m.j.hannon@bham.ac.uk

c Departamento Quimica Inorganica, Universidad Autonoma de Madrid, Madrid, Spain
E-mail: adoración.gomez@uam.es

Abstract

A range of androgen conjugates with non-conventional platinum(II) complexes have been synthesised with the aim of targeting tumour cells since many display elevated levels of the androgen receptor. The androgenic platinum conjugates are delivered into selected cells with improved efficiency (when compared to their non-steroidal analogues). The act of conjugating an androgen to a platinum(II) complex resulted in synergistic effects between the metallic centre and the steroidal ligand, creating highly potent platinum(II) complexes from the inactive components.

Graphical abstract: An androgenic steroid delivery vector that imparts activity to a non-conventional platinum(ii) metallo-drug

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Article information

DOI
https://doi.org/10.1039/C0DT00838A
Article type
Paper
Submitted
13 Jul 2010
Accepted
16 Sep 2010
First published
29 Oct 2010

Dalton Trans., 2010,39, 11353-11364

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An androgenic steroid delivery vector that imparts activity to a non-conventional platinum(II) metallo-drug

M. Huxley, C. Sanchez-Cano, M. J. Browning, C. Navarro-Ranninger, A. G. Quiroga, A. Rodger and M. J. Hannon, Dalton Trans., 2010, 39, 11353 DOI: 10.1039/C0DT00838A

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