Thermodynamic considerations in co-ordination. Part XVII. Glass and chloride electrode studies of carcinostatic ternary and quaternary complexes of nickel and palladium(II) ions with asparaginate and chloride ligands
Abstract
Glass and chloride electrode studies at 25° and I= 3·00M(Na+)ClO4– have been used to express the equilibria involved in the NiII–asparaginate–Cl––OH– and PdII–asparaginate–Cl––OH– systems in terms of formation constants for the following complexes: NiCl+, Ni(asn)Cl, Ni(asn)2Cl–, Ni(asn)2ClOH2– and Pd(asn)H2+, Pd(asn)OH, Pd(asn)ClOH–, Pd(asn)ClH+. The relationship between the compositions of these complexes and carcinostatic activity is discussed.