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Issue 8, 2014
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Photodissociation mass spectrometry: new tools for characterization of biological molecules

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Abstract

Photodissociation mass spectrometry combines the ability to activate and fragment ions using photons with the sensitive detection of the resulting product ions by mass spectrometry. This combination affords a versatile tool for characterization of biological molecules. The scope and breadth of photodissociation mass spectrometry have increased substantially over the past decade as new research groups have entered the field and developed a number of innovative applications that illustrate the ability of photodissociation to produce rich fragmentation patterns, to cleave bonds selectively, and to target specific molecules based on incorporation of chromophores. This review focuses on many of the key developments in photodissociation mass spectrometry over the past decade with a particular emphasis on its applications to biological molecules.

Graphical abstract: Photodissociation mass spectrometry: new tools for characterization of biological molecules

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Publication details

The article was received on 03 Dec 2013 and first published on 30 Jan 2014


Article type: Review Article
DOI: 10.1039/C3CS60444F
Citation: Chem. Soc. Rev., 2014,43, 2757-2783
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    Photodissociation mass spectrometry: new tools for characterization of biological molecules

    J. S. Brodbelt, Chem. Soc. Rev., 2014, 43, 2757
    DOI: 10.1039/C3CS60444F

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