Jump to main content
Jump to site search

Issue 17, 2013
Previous Article Next Article

Stimuli responsive synthetic polypeptides derived from N-carboxyanhydride (NCA) polymerisation

Author affiliations

Abstract

The progress in NCA polymerisation combined with advanced orthogonal functionalization techniques as well as the integration with other controlled polymerisation techniques significantly widened the scope of polypeptide building blocks in a variety of material designs. Well-defined synthetic stimuli-responsive polypeptides (“smart” polypeptides) with incorporated different functionalities have been extensively explored over the past decades. Their significant potential lies in the fact that they combine natural and synthetic elements both contributing to their properties. These novel materials have potential applications in biomedicine and biotechnology including tissue engineering, drug delivery and biodiagnostics. Responsive polypeptides are capable of undergoing conformational changes and phase transition accompanied by variations in the chemical and physical changes of the polypeptides in response to an external stimulus such as biologically relevant species (i.e. biomolecules), the environment (i.e. temperature, pH), irradiation with light or exposure to a magnetic field. In this review, the recent developments including synthetic strategies and applications of synthetic stimuli-responsive homo- and block polypeptides are reviewed.

Graphical abstract: Stimuli responsive synthetic polypeptides derived from N-carboxyanhydride (NCA) polymerisation

Back to tab navigation
Please wait while Download options loads

Publication details

The article was received on 15 Feb 2013, published on 01 May 2013 and first published online on 01 May 2013


Article type: Review Article
DOI: 10.1039/C3CS60063G
Citation: Chem. Soc. Rev., 2013,42, 7373-7390
  •   Request permissions

    Stimuli responsive synthetic polypeptides derived from N-carboxyanhydride (NCA) polymerisation

    J. Huang and A. Heise, Chem. Soc. Rev., 2013, 42, 7373
    DOI: 10.1039/C3CS60063G

Search articles by author