Jump to main content
Jump to site search

Issue 1, 2013
Previous Article Next Article

Targeting and delivery of platinum-based anticancer drugs

Author affiliations

Abstract

Platinum-based anticancer drugs occupy a crucial role in the treatment of various malignant tumours. However, the efficacy and applicability of platinum drugs are heavily restricted by severe systemic toxicities and drug resistance. Different drug targeting and delivery (DTD) strategies have been developed to prevent the shortcomings of platinum-based chemotherapy. These approaches can be roughly categorized into two groups; namely, active and passive tactics. Active DTD is realized through specific molecular interactions between the drugs and cell or tissue elements, while passive DTD is achieved by exploiting the enhanced permeability and retention effect in tumour tissues. The principal methods for active DTD include conjugation of platinum drugs with selective targeting moieties or encapsulation of platinum drugs in host molecules. Bioactive substances such as hormones, carbohydrates, bisphosphonates, peptides and proteins are commonly used in active DTD. Passive DTD generally involves the fabrication of functionalized polymers or nanoparticles and the subsequent conjugation of platinum drugs with such entities. Polymeric micelles, liposomes, nanotubes and nanoparticles are frequently used in passive DTD. In some cases, both active and passive mechanisms are involved in one DTD system. This review concentrates on various targeting and delivery techniques for improving the efficacy and reducing the side effects of platinum-based anticancer drugs. The content covers most of the related literatures published since 2006. These innovative tactics represent current state-of-the-art developments in platinum-based anticancer drugs.

Graphical abstract: Targeting and delivery of platinum-based anticancer drugs

Back to tab navigation

Publication details

The article was received on 13 Jul 2012 and first published on 05 Oct 2012


Article type: Review Article
DOI: 10.1039/C2CS35259A
Citation: Chem. Soc. Rev., 2013,42, 202-224
  •   Request permissions

    Targeting and delivery of platinum-based anticancer drugs

    X. Wang and Z. Guo, Chem. Soc. Rev., 2013, 42, 202
    DOI: 10.1039/C2CS35259A

Search articles by author

Spotlight

Advertisements