Issue 8, 2012
From the journal:

Chemical Society Reviews

The impact of plant–pathogen studies on medicinal drug discovery

Christian Ottmann,*a   Renier A. L. van der Hoornb  and  Markus Kaiser*c  

* Corresponding authors

a Chemical Genomics Centre of the Max Planck Society, Otto-Hahn-Str. 15, 44227 Dortmund, Germany
E-mail: christian.ottmann@cgc.mpg.de
Fax: +49 231 133 2499

b Plant Chemetics Lab, Max Planck Institute for Plant Breeding Research, Carl-von-Linné Weg 10, 50829 Cologne, Germany

c Zentrum für Medizinische Biotechnologie, Fakultät für Biologie, Universität Duisburg-Essen, Universitätsstr. 2, 45117 Essen, Germany
E-mail: markus.kaiser@uni-due.de
Fax: +49 201 183 4982

Abstract

The pharmaceutical industry is reliant on a constant supply of new chemical entities and molecular targets for disease intervention. In this tutorial review, we want to illustrate that basic research studies on the biological function of natural products involved in plant–pathogen interactions can serve as an inspiring source for the identification of new bioactive entities as well as of strategies on how to achieve small molecule manipulation of biological systems. An application of findings from plant–pathogen interaction studies might therefore display a significant impact on drug discovery.

Graphical abstract: The impact of plant–pathogen studies on medicinal drug discovery

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Article information

DOI
https://doi.org/10.1039/C2CS15301G
Article type
Tutorial Review
Submitted
08 Nov 2011
First published
01 Feb 2012

Chem. Soc. Rev., 2012,41, 3168-3178

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The impact of plant–pathogen studies on medicinal drug discovery

C. Ottmann, R. A. L. van der Hoorn and M. Kaiser, Chem. Soc. Rev., 2012, 41, 3168 DOI: 10.1039/C2CS15301G

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