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Issue 2, 2012
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Peptidic foldamers: ramping up diversity

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Abstract

Non-natural folded polymers (foldamers) display considerable versatility, and the design of such molecules is of great current interest. In this respect, peptidic foldamers are perhaps the best-characterized systems, as they populate a number of residue-controlled secondary structures, which have found various biological applications and have also led to the creation of nanostructured materials. This critical review covers recent developments related to diverse building blocks and modern foldamer design principles, such as the stereochemical patterning methods. The recent achievements concerning tertiary/quaternary structures and the self-assembling foldameric nanostructures are also addressed (176 references).

Graphical abstract: Peptidic foldamers: ramping up diversity

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Publication details

The article was received on 12 Apr 2011 and first published on 19 Jul 2011


Article type: Critical Review
DOI: 10.1039/C1CS15097A
Citation: Chem. Soc. Rev., 2012,41, 687-702
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    Peptidic foldamers: ramping up diversity

    T. A. Martinek and F. Fülöp, Chem. Soc. Rev., 2012, 41, 687
    DOI: 10.1039/C1CS15097A

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