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Issue 11, 2011
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The MXCXXC class of metallochaperone proteins: model studies

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Abstract

Transition metal ions can be both beneficial and harmful to biological systems if not carefully regulated. A family of proteins that include a conserved sequence in their binding site of MXCXXC is responsible for delivery and homeostasis of different metals. Model studies present an effective tool for studying the parameters governing metal affinity, selectivity and other mechanistic aspects. Small-molecule, peptide-based, and advanced models will be presented, as well as functional models of potential industrial applications.

Graphical abstract: The MXCXXC class of metallochaperone proteins: model studies

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Publication details

The article was received on 31 Mar 2011 and first published on 22 Jun 2011


Article type: Tutorial Review
DOI: 10.1039/C1CS15086C
Citation: Chem. Soc. Rev., 2011,40, 5282-5292
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    The MXCXXC class of metallochaperone proteins: model studies

    M. S. Shoshan and E. Y. Tshuva, Chem. Soc. Rev., 2011, 40, 5282
    DOI: 10.1039/C1CS15086C

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