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Issue 7, 2011
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Domino reactions for the synthesis of bridged bicyclic frameworks: fast access to bicyclo[n.3.1]alkanes

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Abstract

In the current bid for synthetic efficiency, multiple bond-forming transformations are becoming a key concept in organic synthesis. In this context, domino protocols have become increasingly common in the synthesis of bicyclic systems. This tutorial review aims at providing a short but authoritative overview of this topic, focusing on the preparation of bridged bicyclo[n.3.1]alkane systems, and is organized according to the number of rings created in the key domino process.

Graphical abstract: Domino reactions for the synthesis of bridged bicyclic frameworks: fast access to bicyclo[n.3.1]alkanes

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Publication details

The article was received on 14 Jan 2011 and first published on 11 Apr 2011


Article type: Tutorial Review
DOI: 10.1039/C1CS15018A
Citation: Chem. Soc. Rev., 2011,40, 3445-3454
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    Domino reactions for the synthesis of bridged bicyclic frameworks: fast access to bicyclo[n.3.1]alkanes

    M. Ruiz, P. López-Alvarado, G. Giorgi and J. C. Menéndez, Chem. Soc. Rev., 2011, 40, 3445
    DOI: 10.1039/C1CS15018A

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