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Issue 2, 2010
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Recent synthetic approaches towards the antiproliferative natural products avrainvillamide and stephacidin B

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Abstract

Due to their strong antiproliferative activity and their unprecedented structural complexity within the class of indole alkaloids, avrainvillamide and stephacidin B have recently attracted considerable interest from the synthetic community. To date, three distinct approaches towards these molecules have been disclosed and the present tutorial review aims at comparing all three syntheses with a focus on the various strategies and methods employed. Besides, recent progress towards the synthesis of structural analogs and the identification of the biological target of avrainvillamide will be presented.

Graphical abstract: Recent synthetic approaches towards the antiproliferative natural products avrainvillamide and stephacidin B

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Publication details

The article was received on 30 Mar 2009 and first published on 14 Dec 2009


Article type: Tutorial Review
DOI: 10.1039/B900407F
Citation: Chem. Soc. Rev., 2010,39, 591-599
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    Recent synthetic approaches towards the antiproliferative natural products avrainvillamide and stephacidin B

    C. F. Nising, Chem. Soc. Rev., 2010, 39, 591
    DOI: 10.1039/B900407F

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