Issue 5, 2008
From the journal:

Chemical Society Reviews

Intracellular applications of analytical SERS spectroscopy and multispectral imaging

Igor Chourpa,bc   Franck H. Lei,a   Pierre Dubois,bc   Michel Manfaita  and  Ganesh D. Sockalingum*a  

* Corresponding authors

a MéDIAN, Université de Reims Champagne-Ardenne, CNRS UMR6237 – MEDyC, UFR de Pharmacie, 51 rue Cognacq-Jay, 51096 Reims cedex, France
E-mail: ganesh.sockalingum@univ-reims.fr
Fax: +33 (0)3 26 91 35 50
Tel: +33 (0)3 26 91 35 53

b Université François-Rabelais, Faculté de Pharmacie, “Focalisation magnétique d’agents anticancéreux”, 31 avenue Monge, F-37200 Tours, France
E-mail: chourpa@univ-tours.fr
Fax: +33 (0)2 47367270
Tel: +33 (0)247367162

c Institut Fédératif de Recherche 135 “Imagerie Fonctionnelle”, F-37000 Tours, France

Abstract

The aim of this tutorial review is to give an overview of the state of the art of intracellular applications of analytical SERS spectroscopy. We pay particular attention to nanoparticle-based SERS spectroscopy since this currently dominates the published literature on non-disturbing analysis of live cells. We describe recent advances in this domain due to the development of multispectral imaging and to the combined use of SERRS (surface-enhanced resonance Raman scattering) and fluorescence spectroscopy. Finally, a perspective view is given on the tip-based approaches like tip-enhanced Raman spectroscopy (TERS) which allow micrometric and nanometric resolution.

Graphical abstract: Intracellular applications of analytical SERS spectroscopy and multispectral imaging

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Article information

DOI
https://doi.org/10.1039/B714732P
Article type
Tutorial Review
Submitted
14 Feb 2008
First published
26 Mar 2008

Chem. Soc. Rev., 2008,37, 993-1000

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Intracellular applications of analytical SERS spectroscopy and multispectral imaging

I. Chourpa, F. H. Lei, P. Dubois, M. Manfait and G. D. Sockalingum, Chem. Soc. Rev., 2008, 37, 993 DOI: 10.1039/B714732P

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