Issue 1, 2008

Organocatalysed asymmetric Mannich reactions

Abstract

The asymmetric Mannich reaction ranks among the most potent enantioselective and diastereoselective C–C-bond forming reactions. In recent years, organocatalysed versions of asymmetric Mannich processes have been increasingly reported and used in a rapidly growing number of applications. This tutorial review provides an overview of the recent history of the asymmetric organocatalysed Mannich reaction, including scope and limitations, and application of different catalyst systems.

Graphical abstract: Organocatalysed asymmetric Mannich reactions

Article information

Article type
Tutorial Review
Submitted
28 Sep 2007
First published
30 Oct 2007

Chem. Soc. Rev., 2008,37, 29-41

Organocatalysed asymmetric Mannich reactions

J. M. M. Verkade, L. J. C. V. Hemert, P. J. L. M. Quaedflieg and F. P. J. T. Rutjes, Chem. Soc. Rev., 2008, 37, 29 DOI: 10.1039/B713885G

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